Understanding GLP-1: Your Body’s Natural Appetite Regulator
How GLP-1 Affects Appetite, Metabolism, and Weight Loss
When it comes to appetite control, blood sugar balance, and metabolic health, one hormone is gaining a lot of attention—glucagon-like peptide-1 (GLP-1). GLP-1 medications are incredible tools, and I prescribe them often. However, they’re not the right fit for everyone. Cost can be a barrier, and in some cases, there are medical reasons these medications must be avoided.
While many people are familiar with insulin, GLP-1 plays a critical but lesser-known role in regulating blood sugar and supporting weight loss. Let’s take a closer look at how it works—and how you may be able to support healthy GLP-1 levels naturally.
What Is GLP-1?
GLP-1 is an incretin hormone, released by the L-cells of the small intestine in response to eating. One of its key functions is to suppress the release of glucagon, a hormone that increases blood sugar by prompting the liver to break down stored glycogen (a form of glucose).
Think of insulin and glucagon as opposites:
Insulin lowers blood glucose
Glucagon raises it
GLP-1 helps balance this system after meals by promoting insulin and reducing glucagon, depending on blood glucose levels
Where Does GLP-1 Work in the Body?
GLP-1 receptors are found in several organs and systems:
Pancreas
Stomach and gastrointestinal tract
Brain (particularly the hypothalamus)
Blood vessels
GLP-1 has many important actions:
Suppresses glucagon, reducing glucose release from the liver
Delays gastric emptying, helping you feel full longer
Stimulates satiety centers in the brain, reducing appetite
Activates the vagus nerve, supporting the gut-brain connection
May support reduced inflammation, promoting better metabolic health (research is ongoing)
What Affects GLP-1 Levels?
Certain lifestyle factors can reduce your natural GLP-1 production. Two of the biggest disruptors are:
Obesity
Poor sleep
These conditions can blunt GLP-1 secretion and signaling, making it harder to regulate appetite and blood sugar effectively.
How to Support Healthy GLP-1 Levels Naturally
While GLP-1-based medications are gaining popularity for weight loss, research suggests several natural strategies may enhance your body’s own GLP-1 response:
1. Drink Yerba Mate
This traditional South American tea contains compounds that may promote GLP-1 secretion. A 2025 study suggests that metabolites like ferulic acid may be involved, but more human research is needed.
2. Use Allulose as a Sweetener
Allulose is a low-calorie sweetener that doesn’t spike blood sugar and has shown promise in increasing GLP-1 levels in small human trials. Some people may experience mild digestive discomfort.
3. Follow a Low-Carb, High-Protein Diet
A balanced diet supports metabolic hormones like GLP-1. Aim to:
Limit refined carbohydrates
Prioritize protein at each meal
Include healthy fats for satiety and hormone support
4. Add Collagen to Your Routine
Some early studies suggest collagen peptides might influence GLP-1 levels, although this research is still developing. High-quality protein also supports your body’s natural collagen production.
The Bottom Line
GLP-1 is a powerful hormone with wide-ranging effects on appetite, blood sugar regulation, and metabolic health. Supporting your body’s natural GLP-1 function through nutrition, sleep, and lifestyle habits can be a helpful strategy—whether or not you use medication.
Understanding and nurturing your GLP-1 system is an empowering way to take charge of your health naturally and sustainably.
How We Can Help
If you're interested in personalized guidance to support your metabolic health, schedule a consultation with our clinic today. We're here to help you feel your best!
Here’s what to expect:
A consultation to gather your medical history
Lab testing to evaluate your current metabolic health
A customized plan to help you optimize your health and energy
References
Cooper-Leavitt, E. T., et al. (2025). The incretin effect of yerba maté (Ilex paraguariensis) is partially dependent on gut-mediated metabolism of ferulic acid. Nutrients, 17(4), 625. https://doi.org/10.3390/nu17040625
Fukunaga, K., et al. (2023). A pilot study on the efficacy of a diabetic diet containing the rare sugar D-allulose in patients with type 2 diabetes mellitus. Nutrients, 15(12), 2802. https://doi.org/10.3390/nu15122802
Disclaimer
This blog post is for educational purposes only and does not constitute medical advice. Always consult with your healthcare provider before making changes to your diet, lifestyle, or medications.
